Medorex fluid-bed-bioreactor offers excellent and varied possibilities for the cultivation of functioning tissue and adherent cells which need a carrier material for her growth. The fluid-bed bioreactor can be used in the medical research, e.g., in the cultivation of the functioning liver cells, cartilages and flat skin cells. Moreover it can be used in environment protection and pharmaceutical research and development.
In the medical field are removed by biopsy some functional body's cells and cultivated in a culture bottle with specific medium. These cells are transmitted on the special carrier pads of degradable polymers, porous ceramics or fleece in the multi-well flow chamber. The cells are cultivaed until tissue cultures are grown with the corresponding properties. The developed tissue cultures can be removed enzymatic and processed. The tissue cultivation process is carried out in an incubator at the optimum temperature. The needed medium for the tissue cultivation is prepared outside of the chamber with the nutrients which are necessary for the growth of the cells. The nutritious medium is pumped by a peristaltic pump continuous and slowly to the cells in the fluid-bed chamber. The spent medium is removed by means of a pump from the chamber. The aeration of the cells occurs directly by means of convection. In this way, the tissues cells are optimally supplied with oxygen and nutrients and can grow continue. The fluid-bed bioreactor can be used also in production of the eukaryotic proteins, monoclonal antibodies and other cell contents substances of pharmaceutical research. In addition, they find their use with the help of special bacteria in the preliminary examinations and tests of the biotechnology, e.g. at the reduction of pollutions in the wastewater or in the ground.